Retinoic Acid-Induced Differentiation in SK-N-SH Cells

Retinoic acid (RA) is known to induce differentiation in various cell types, including SK-N-SH cells. Upon RA treatment, SK-N-SH cells undergo morphological and biochemical changes characteristic of mature neurons, such as neurite outgrowth and expression of neuronal markers. This differentiation model helps researchers understand the pathways involved in neuronal maturation and the potential role of RA in neurodevelopmental processes. Furthermore, it serves as a platform to study the effects of neurotoxic agents and to evaluate neuroprotective compounds.